The establishment of EVISA is funded by the EU through
the Fifth Framework Programme (G7RT- CT- 2002- 05112).
Supporters of EVISA includes:
Bis(maltolato)oxovanadium(IV) (BMOV) can be synthesized by simple metathesis of vanadyl sulfate trihydrate and maltol (3-hydroxy-2-methyl-4-pyrone) (1:2). The ligand itself is commercially available and is an approved food additive in many countries, including Canada, the United Kingdom, and the United States. BMOV can be prepared in >90% yield in water, has a molecular weight of 317 and is soluble (millimolar scale) in a number of organic solvents as well as water. These properties together (neutral charge and aqueous solubility) contribute to high oral bioavailability. With these considerations in mind, the pentacoordinate, oxovanadium(IV) complex was developed, specifically as a potential insulin-mimetic agent.