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Jürgen Gailer
Associate Professor
Department of Chemistry, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada
++1 - 403-210-8899
++1 - 403-289-9488
Jürgen  Gailer
jgailer@ucalgary.ca
http://www.ucalgary.ca/jgailer/
  • structurally characterize toxicologically important metabolites that are formed between toxic metals/metalloid compounds and endogenous thiols and dithiols as well as synthetic ones (chelating agents);
  • probe the comparative stability of the aforementioned metabolites under simulated physiological conditions;
  • establish the molecular basis of known antagonistic and synergistic interactions in mammals that involve the simultaneous administration of an essential and a toxic metal/metalloid compound;
  • study the competitive interaction between individual toxic metals/metalloid compounds and multiple endogenous ligands;
  • probe the biotransformation of clinically used anticancer metallodrugs in human blood plasma in vitro
  • SEC-FAAS, SEC-ICP-AES, SEC-ICP-MS,
  • 77Se-NMR,
  • ESI-MS,
  • XANES, EXAFS  (in collaboration with Dr. G.N. George and I.J. Pickering)



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