WHO Library Cataloguing-in-Publication

Data Manganese and its compounds. (Concise international chemical assessment document ; 12)

1.Manganese - adverse effects
2.Manganese - toxicity
3.Environmental exposure
4.Maximum permissible exposure level
I.International Programme on Chemical Safety
II.Series ISBN 92 4 153012 X (NLM classification: QV 290) ISSN 1020-6167

TABLE OF CONTENTS

    FOREWORD

    1. EXECUTIVE SUMMARY

    2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES

    3. ANALYTICAL METHODS

    4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE

    5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION

    6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE

              6.1. Environmental levels
              6.2. Human exposure

    7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS

    8. EFFECTS ON LABORATORY MAMMALS AND  IN VITRO TEST SYSTEMS

              8.1. Single exposure
              8.2. Irritation and sensitization
              8.3. Short-term exposure
              8.4. Long-term exposure
                   8.4.1. Subchronic exposure
                   8.4.2. Chronic exposure and carcinogenicity
              8.5. Genotoxicity and related end-points
              8.6. Reproductive and developmental toxicity
              8.7. Immunological and neurological effects

    9. EFFECTS ON HUMANS

         9.1. Case reports
         9.2. Epidemiological studies

    10. EFFECTS EVALUATION

              10.1. Evaluation of health effects
                   10.1.1. Hazard identification and dose-response assessment
                   10.1.2. Criteria for setting guidance values for manganese
                   10.1.3. Sample risk characterization

    11. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES

    12. HUMAN HEALTH PROTECTION AND EMERGENCY ACTION

              12.1. Human health hazards
              12.2. Advice to physicians
              12.3. Health surveillance programme

    13. CURRENT REGULATIONS, GUIDELINES, AND STANDARDS

         INTERNATIONAL CHEMICAL SAFETY CARD

         REFERENCES

         APPENDIX 1 -- SOURCE DOCUMENTS

         APPENDIX 2 -- CICAD PEER REVIEW

         APPENDIX 3 -- CICAD FINAL REVIEW BOARD

         APPENDIX 4 -- ADDITIONAL APPROACHES FOR GUIDANCE VALUE
         DEVELOPMENT

         RÉSUMÉ D'ORIENTATION

         RESUMEN DE ORIENTACION