US FDA: Elemental Analysis Manual: Section 4.10: HPLC-ICP-MS Determination of Four Arsenic Species in Fruit Juice
This method describes a procedure for using high performance liquid chromatography (HPLC) in combination with inductively coupled plasma-mass spectrometry (ICP-MS) to determine inorganic arsenic (both arsenite (AsIII) and arsenate (AsV)) in clear (free of solids) fruit juice. Dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) are also determined with this method. Arsenobetaine (AsB) is included in the multi-analyte working standard solution as a representative unretained arsenic-containing species in order to ensure adequate separation from As(III). Other matrices may be analyzed by this procedure if performance is verified in the matrix of interest and at the concentration of interest. The limits listed in 4.10 Table 1 are presented as an example of results achievable using the method and equipment specified herein and will vary depending on instrumentation and actual operating conditions.