|Vacancy: || Royal Surrey NHS Foundation Trust, Guildford, Surrey, UK: Senior Healthcare Scientist|
Posting date: 17.03.2021
|Type: || Postdoctoral fellowships |
The Royal Surrey NHS Foundation Trust is looking for an energetic, enthusiastic and highly-motivated scientist to join the Supra-Regional Assay Service (SAS) Trace Element Laboratory, as part of the Wilson’s Disease Centre of Excellence at the Royal Surrey Hospital in Guildford.
The SAS Laboratory is part of Berkshire and Surrey Pathology
Services, a joint venture between Ashford & St Peter's Hospital NHS
Foundation Trust, Frimley Health NHS Foundation Trust, Royal Berkshire
Foundation Trust and Royal Surrey Hospital NHS Foundation Trust.
The position available is in the SAS Trace Element Laboratory, based
at 15 Frederick Sanger Road, on the Surrey Research Park in Guildford.
The laboratory is very well equipped with instrumentation used for the
measurement of trace elements in clinical samples. This includes
inductively coupled plasma mass spectrometry (ICP-MS), high performance
liquid chromatography (HPLC) coupled to ICP-MS/MS and auto-analysers for
enzymatic assays. The position will be an important part of the
Wilson’s Disease Centre of Excellence based at the RSH. Wilson’s
disease is an inherited metabolic abnormality in copper metabolism which
affects approximately 1 in 30000 people. As a result of it’s rarity and
diverse clinical presentation patients are often difficult to diagnose
and can suffer from unwanted treatment side-effects. For this reason the
development of new analytical tools for the study and characterisation
of patients is required.
The role of this position is to develop and undertake novel
investigations using HPLC coupled to triple quadrupole inorganic mass
spectrometry (ICP-MS/MS) to develop protocols for the greater
understanding of the function of copper. Also to manage and undertake
the analysis of samples using enzyme activity and immunochemical assays,
as well as routine serum and urine copper analysis. These methods will
then be used to investigate samples from a Wilson’s disease patient
Registry in an effort to elucidate the characteristics of the patients
involved in the Registry study.
An ideal candidate would have a keen eye for detail and also
experience of carrying out method validation and research and
development projects, including the preparation of papers on research
studies undertaken. Ideally educated to PhD level in chemistry or
analytical chemistry, with post-graduation experience in HPLC-ICP-MS/MS.
Candidates with an extensive knowledge of the specialist area of
trace elements in human health, acquired through post-graduate studies
or equivalent experience and an ability to carry out highly technical
R&D projects, from inception, through delivery and reporting, would
also be considered. Applications from candidates with experience of
using electrospray tandem mass spectrometry or other forms of organic MS
would also be welcome. An in-depth knowledge and experience of
ICP-MS/MS instrumentation, theory and practice, including coupling to
chromatographic systems is an important requirement for the role.
Applications for full or part-time working would be considered.
Our staff benefit from a strong commitment to training and development.
If you think your skills would add to our team please contact Dr Chris Harrington in the first instance on 01483 689977 or e-mail firstname.lastname@example.org. Recruitment will be continued until a suitable candidate for the position has been recruited.