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The establishment of EVISA is funded by the EU through the Fifth Framework Programme (G7RT- CT- 2002- 05112).

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Vacancy:   Royal Surrey NHS Foundation Trust, Guildford, Surrey, UK: Senior Healthcare Scientist

The SAS Laboratory is part of Berkshire and Surrey Pathology Services, a joint venture between Ashford & St Peter's Hospital NHS Foundation Trust, Frimley Health NHS Foundation Trust, Royal Berkshire Foundation Trust and Royal Surrey Hospital NHS Foundation Trust.

The position available is in the SAS Trace Element Laboratory, based at 15 Frederick Sanger Road, on the Surrey Research Park in Guildford.  The laboratory is very well equipped with instrumentation used for the measurement of trace elements in clinical samples.  This includes inductively coupled plasma mass spectrometry (ICP-MS), high performance liquid chromatography (HPLC) coupled to ICP-MS/MS and auto-analysers for enzymatic assays. The position will be an important part of the Wilson’s Disease Centre of Excellence based at the RSH.  Wilson’s disease is an inherited metabolic abnormality in copper metabolism which affects approximately 1 in 30000 people. As a result of it’s rarity and diverse clinical presentation patients are often difficult to diagnose and can suffer from unwanted treatment side-effects. For this reason the development of new analytical tools for the study and characterisation of patients is required.

The role of this position is to develop and undertake novel investigations using HPLC coupled to triple quadrupole inorganic mass spectrometry (ICP-MS/MS) to develop protocols for the greater understanding of the function of copper. Also to manage and undertake the analysis of samples using enzyme activity and immunochemical assays, as well as routine serum and urine copper analysis. These methods will then be used to investigate samples from a Wilson’s disease patient Registry in an effort to elucidate the characteristics of the patients involved in the Registry study.

An ideal candidate would have a keen eye for detail and also experience of carrying out method validation and research and development projects, including the preparation of papers on research studies undertaken. Ideally educated to PhD level in chemistry or analytical chemistry, with post-graduation experience in HPLC-ICP-MS/MS.

Candidates with an extensive knowledge of the specialist area of trace elements in human health, acquired through post-graduate studies or equivalent experience and an ability to carry out highly technical R&D projects, from inception, through delivery and reporting, would also be considered. Applications from candidates with experience of using electrospray tandem mass spectrometry or other forms of organic MS would also be welcome. An in-depth knowledge and experience of ICP-MS/MS instrumentation, theory and practice, including coupling to chromatographic systems is an important requirement for the role. Applications for full or part-time working would be considered.

Our staff benefit from a strong commitment to training and development.

If you think your skills would add to our team please contact Dr Chris Harrington in the first instance on 01483 689977 or e-mail chris.harrington1@nhs.net. Recruitment will be continued until a suitable candidate for the position has been recruited.
Homepage: https://www.jobs.nhs.uk/xi/vacancy/916432385

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