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The establishment of EVISA is funded by the EU through the Fifth Framework Programme (G7RT- CT- 2002- 05112).


Supporters of EVISA includes:

Scientific publications with participation of EVISA



Research supported by EVISA is meant to:
  • provide easy and robust methods for speciation analysis
  • enhance the quality of analytical results and the information provided by speciation analysis
  • enhance the knowledge about the biological activity, function and toxicity of chemical species
The following studies were done with EVISA participation (newest first):


Stefanie Fingerhut, Ann-Christin Niehoff, Michael Sperling, Astrid Jeibmann, Werner Paulus, Thomas Niederstadt, Thomas Allkemper, Walter Heindel, Markus Holling, Uwe Karst, Spatially resolved quantification of gadolinium deposited in the brain of a patient treated with gadolinium-based contrast agents, J. Trace Elem. Med. Biol., 45 (2018) 125-130. DOI: 10.1016/j.jtemb.2017.10.004

G.M. Thyssen, M. Holtkamp, H. Kaulfürst-Soboll, C.A. Wehe, M. Sperling,  A. von Schaewen, U. Karst, Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles,  Metallomics, 9/6 (2017) 676-684. doi:  10.1039/C7MT00003K

David Clases, Marvin Birka, Michael Sperling, Andreas Faust, Uwe Karst, Isobaric dilution analysis as a calibration tool for long lived radionuclides in ICP-MS, J. Trace Elem. Med. Biol., 40 (2017) 97–103. DOI: 10.1016/j.jtemb.2017.01.002

Marvin Birka, Jörg Roscher, Michael Holtkamp, Michael Sperling, Uwe Karst, Investigating the stability of gadolinium based contrast agents towards UV radiation, Water Res., 91 (2016) 244-250. DOI: 10.1016/j.watres.2016.01.012

Oliver Hachmöller, Ana Guilherme Buzanich, Michaela Aichler, Martin Radtke, Dörthe Dietrich, Kristina Schwamborn, Lisa Lutz, Martin Werner, Michael Sperling, Axel Walch and Uwe Karst, Elemental bioimaging and speciation analysis for the investigation of Wilson’s disease using µXRF and XANES, Metallomics, 8 (2016) 648-653. DOI: 10.1039/c6mt00001k

Marvin Birka, Christoph A. Wehe, Oliver Hachmöller, Michael Sperling, Uwe Karst, Tracing gadolinium-based contrast agents from surface water to drinking water by means of speciation analysis, J. Chromatogr. A, 1440 (2016) 105-111. DOI: 10.1016/j.chroma.2016.02.050

Oliver Hachmöller, Michaela Aichler, Kristina Schwamborn, Lisa Lutz, Martin Werner, Michael Sperling, Axel Walch, Uwe Karst, Element bioimaging of liver needle biopsy specimens from patients with Wilson’s disease by laser ablation-inductively coupled plasma-mass spectrometry, J. Trace Elem. Med.  Biol., 35 (2016) 97–102. DOI: 10.1016/j.jtemb.2016.02.001

Jens Hogeback, Miriam Schwarzer, Christoph A. Wehe, Michael Sperling and Uwe Karst, Investigating the adduct formation of organic mercury species with carbonic anhydrase and hemoglobin from human red blood cell hemolysate by means of LC/ESI-TOF-MS and LC/ICP-MS, Metallomics, 8 (2016) 101-107. DOI: 10.1039/c5mt00186b

Chun Kong Mak, Christoph A. Wehe, Michael Sperling, Uwe Karst, Identification and quantification of electrochemically generatedmetabolites of thyroxine by means of liquidchromatography/electrospray-mass spectrometry andcountergradient liquid chromatography/inductively coupled plasma-mass spectrometry, J. Chromatogr. A, 1419 (2015) 81–88. DOI: 10.1016/j.chroma.2015.09.076

C. Köppen, O. Reifschneider, I. Castanheira, M. Sperling, U. Karst and G. Ciarimboli, Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin, Metallomics, 7 (2015) 1595-1603. DOI: 10.1039/c5mt00226e

Rebecca Niehaus, Michael Sperling and Uwe Karst, Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS, J. Anal. At. Spectrom., 30 (2015) 2056-2065. DOI: 10.1039/c5ja00221d

Christoph A. Wehe, Georgina M. Thyssen, Christina Herdering, Indra Raj, Giuliano Ciarimboli, Michael Sperling, Uwe Karst, Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2015. doi: 10.1007%2Fs13361-015-1141-y

Olga Reifschneider, Kristina S. Wentker, Klaus Strobel, Rebecca Schmidt, Max Masthoff, Michael Sperling, Cornelius Faber, Uwe Karst, Elemental Bioimaging of Thulium in Mouse Tissues by Laser Ablation-ICPMS as a Complementary Method to Heteronuclear Proton Magnetic Resonance Imaging for Cell Tracking Experiments, Anal. Chem. 2015, 87, 4225-4230. DOI: 10.1021/ac504363q

Olga Reifschneider, Christian L. Schütz, Christoph Brochhausen, Gabriele Hampel, Tobias Ross, Michael Sperling, Uwe Karst, Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy, Anal. Bioanal. Chem.  407 (2015) 2365–2371. DOI 10.1007/s00216-014-8012-4

Marvin Birka, Kristina S. Wentker, Elke Lusmöller, Brigit Arheilger, Christoph A. WeheMichael Sperling, Rudolf Stadler, Uwe Karst, Diagnosis of Nephrogenic Systemic Fibrosis by means of Elemental Bioimaging and Speciation Analysis, Anal. Chem. 87 (2015) 3321-3328. DOI: 10.1021/ac504488k

Christoph A. Wehe, Imke Pieper, Michael Holtkamp, Georgina M. Thyssen, Michael Sperling, Tanja Schwerdtle, Uwe Karst, On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes, Anal Bioanal Chem (2014) 406:1909–1916. DOI 10.1007/s00216-013-7608-4

Christoph A. Wehe, Georg Beyer, Michael Sperling, Giuliano Ciarimboli, Uwe Karst, Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation, J. Trace Elem. Med. Biol. 28 (2014) 166–172. doi: 10.1016/j.jtemb.2014.01.001

Stefan Trümpler, Björn Meermann, Sascha Nowak, Wolfgang Buscher, Uwe Karst, Michael Sperling, In vitro study of thimerosal reactions in human whole blood and plasma surrogate samples, J. Trace Elem. Med. Biol. 28 (2014) 125–130. doi: 10.1016/j.jtemb.2014.01.006

Christoph A. Wehe, Ann-Christin Niehoff, Georgina M. Thyssen, Michael Sperling, Uwe Karst, Rapid cell mode switching and dual laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging, Rapid Commun. Mass Spectrom. 28 (2014) 2627–2635. DOI: 10.1002/rcm.7054

Franziska Blaske, Olga Reifschneider, Georg Gosheger, Christoph A. WeheMichael SperlingUwe Karst, Gregor Hauschild, Steffen Höll, Elemental Bioimaging of Nanosilver-Coated Prostheses Using X-ray Fluorescence Spectroscopy and Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry, Anal. Chem. 86 (2014) 615-620.  doi: 10.1021/ac4028577

Sascha Nowak, Monika Gesell, Michael Holtkamp, Andy Scheffer, Michael Sperling, Uwe Karst, Wolfgang Buscher, Low gas flow inductively coupled plasma optical emission spectrometry for the analysis of food samples after microwave digestion,  Talanta 129(2014)575–578. doi: 10.1016/j.talanta.2014.06.045

Ann-Christin Bülter, Aline Moosmann, Judith Söbbing, Arno Wiehe,  Dennis Mulac, Christoph Alexander Wehe, Olga Reifschneider, Franziska Blaske, Sylvia Wagner, Michael Sperling, Hagen von Briesen, Klaus Langer, Uwe Karst, A Palladium Label to Monitor Nanoparticle-Assisted Drug Delivery of a Photosensitizer into Tumor Spheroids by Elemental Bioimaging,  Metallomics, 6/1 (2014) 77-81. DOI: 10.1039/C3MT00223C

Christina Herdering, Olga Reifschneider, Christoph A. Wehe, Michael Sperling, Uwe Karst, Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry, Rapid Commun. Mass Spectrom., 27 (2013) 2595–2600. DOI: 10.1002/rcm.6727

Christina Herdering, Christoph A. Wehe, Olga Reifschneider, Indra Raj, Giuliano Ciarimboli, Kurt Diebold, Christoph Becker, Michael Sperling, Uwe Karst, Laser ablation based bioimaging with simultaneous elemental and molecular mass spectrometry: towards spatially resolved speciation analysis, Rapid Commun. Mass Spectrom., 27 (2013) 2588–2594. DOI: 10.1002/rcm.6726

Franziska Blaske, Lisa Stork, Michael Sperling, Uwe Karst, Adduct formation of ionic and nanoparticular silver with amino acids and glutathione, J. Nanopart. Res., 15 (2013) 1928. DOI 10.1007/s11051-013-1928-3

Olga Reifschneider, Christoph A. Wehe, Indra Raj, Jens Ehmcke, Giuliano Ciarimboli, Michael Sperling, Uwe Karst, Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS, Metallomics, 5 (2013) 1440-1447. DOI: 10.1039/c3mt00147d

Marvin Birka, Christoph A. Wehe, Lena Telgmann, Michael Sperling, Uwe Karst, Sensitive quantification of gadolinium-based magnetic resonance imaging contrast agents in surface waters using hydrophilic interaction liquid chromatography and inductively coupled plasma sector field mass spectrometry, J. Chromatogr. A, 1308 (2013) 125-131. DOI:    10.1016/j.chroma.2013.08.017

Michael Holtkamp, Tim Elseberg, Christoph A. Wehe, Michael Sperling, Uwe Karst, Complexation and oxidation strategies for improved TXRF determination of mercury in vaccines, J. Anal. At. Spectrom., 28 (2013) 719-723. DOI: 10.1039/c3ja00002h

Olga Reifschneider, Christoph A. Wehe, Kurt Diebold, Christoph Becker, Michael Sperling, Uwe Karst, Elemental bioimaging of haematoxylin and eosin-stained tissues by laser ablation ICP-MS, J. Anal. At. Spectrom., 28 (2013) 989-993. DOI: 10.1039/c3ja50046b

Christine Brauckmann, Christoph A. Wehe, Michael Kieshauer, Claudia Lanvers-Kaminsky,  Michael Sperling, Uwe Karst, The interaction of platinum-based drugs with native biologically relevant proteins, Anal. Bioanal. Chem., 405 (2013) 1855-1864. DOI: 10.1007/s00216-012-6410-z

Christine Brauckmann, Helene Faber, Claudia Lanvers-Kaminsky, Michael Sperling, Uwe Karst, Influence of cimetidine and its metabolites on Cisplatin—Investigation of adduct formation by means of electrochemistry/liquid chromatography/electrospray mass spectrometry, J. Chromatogr. A., 1279 (2013) 49–57. DOI: 10.1016/j.chroma.2012.12.069

Lena Telgmann, Michael Sperling, Uwe Karst, Speciation of Gd-based MRI contrast agents in biological and environmental samples: A review, Anal. Chim. Acta, 764 (2013) 1-16. DOI: 10.1016/j.aca.2012.12.007

Michael Sperling, Uwe Karst, Metallomics: an emerging interdisciplinary science, Anal. Bioanal. Chem., 405/6 (2013) 1789-1790. DOI: 10.1007/s00216-012-6619-x   

L. Telgmann, C.A. Wehe, M. Birka, J. Künnemeyer, S. Nowak, M. Sperling, U. Karst, Speciation and Isotope Dilution Analysis of Gadolinium-Based Contrast Agents in Wastewater, Environ. Sci. Technol., 46 (2012) 11929-11936. DOI: 10.1021/ES301981Z

L. Telgmann, C.A. Wehe, J. Künnemeyer, A.-C. Bülter, M. Sperling, U. Karst, Speciation of Gd-based MRI contrast agents and potential products of transmetalation with iron ions or parenteral iron supplements, Anal. Bioanal. Chem., 404 (2012) 2133-2141. DOI: 10.1007/S00216-012-6404-X

M. Holtkamp, C.A. Wehe, F. Blaske, C. Holtschulte, M. Sperling, U. Karst, Nitrogen purged TXRF for the quantification of silver and palladium, J. Anal. Atomic Spectrom., 27 (2012) 1799-1802. DOI: 10.1039/C2JA30117B

Bjoern Meermann, Michael Sperling, Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications, Anal. Bioanal. Chem., 403 (2012) 1501–1522. DOI: 10.1007/S00216-012-5915-9

Lena Telgmann, H. Faber, S. Jahn, D. Melles, H. Simon, M. Sperling, U. Karst, Identification and Quantification of Potential Metabolites of Gd-Based Contrast Agents by Electrochemistry/Separations/Mass Spectrometry, J. Chromatogr. A, 1240 (2012) 147–155.
DOI: 10.1016/J.CHROMA.2012.03.088

Michael Sperling, Joanna Szpunar, Speciation Issue: Editorial, J. Anal. At. Spectrom., 26 (2011) 22. DOI: 10.1039/c0ja90031a

C.A. Wehe, J. Bornhorst, M. Holtkamp, M. Sperling, H.-J. Galla, Tanja Schwerdtle, U. Karst, Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS, Metallomics, 3/12 (2011) 1291–1296. DOI: 10.1039/C1MT00170A

L. Telgmann, M. Holtkamp, J. Künnemeyer, C. Gelhard, M. Hartmann, A. Klose, M. Sperling, U. Karst, Simple and rapid quantification of gadolinium in urine and blood plasma samples by means of total reflection X-ray fluorescence (TXRF), Metallomics, 30 (2011) 1766-1773. DOI: 10.1039/c1mt00054c

R. Janzen, M. Schwarzer, M. Sperling, M. Vogel, T. Schwerdtle, U. Karst, Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS), Metallomics, 3/8 (2011) 847–852. DOI: 10.1039/C1MT00043H

S. Bomke, M. Sperling, U. Karst, Organometallic derivatizing agents in bioanalysis, Anal. Bioanal. Chem., 397 (2010) 3483-3494. DOI: 10.1007/s00216-010-3611-1

A. Wilken, R. Janzen, M. Holtkamp, S. Nowak, M. Sperling, M. Vogel, U. Karst, Investigation of the interaction of Mercurochrome constituents with proteins using liquid chromatography/mass spectrometry, Anal. Bioanal. Chem., 397 (2010) 3525-3532. DOI: 10.1007/S00216-010-3842-1

S. Trümpler, S. Nowak, B. Meermann, G. A. Wiesmüller, W. Buscher, M. Sperling, U. Karst, Detoxification of mercury species—an in vitro study with antidotes in human whole blood , Anal. Bioanal. Chem., 395 (2009) 1929-1935. DOI: 10.1007/s00216-009-3105-1

S. Trümpler, W. Lohmann, B. Meermann, W. Buscher, M. Sperling, U. Karst, Interaction of Thimerosal with Proteins - Ethylmercury Adduct Formation of Human Serum Albumin and b-Lactoglobulin A, Metallomics, 1 (2009) 87-91. DOI: 10.1039/b815978e

Kevin Francesconi, Michael Sperling, Speciation analysis with HPLC-mass spectrometry: time to take stock, The Analyst, 130 (2005) 998-1001. DOI: 10.1039/b504485p

M. Sperling, W. Buscher, O.F.X. Donard, R. Cornelis, L. Ebdon, Transfer of Know-how and Knowledge in the Area of Speciation Analysis from research Institutions to Industry - The European Virtual Institute for Speciation Analysis (EVISA), RMZ-Materials and Geoenvironment, 51 (2004) 2030-2032.

R. Cornelis, W. Buscher, M. Sperling, O.F.X. Donard, N. Proust, E. Rosenberg, R. Milacic, The EC networking on elemental speciation revisited, Accred. Qual. Assur., 9 (2004) 268-271 (2004). DOI: 10.1007/s00769-004-0761-x



last time modified: June 21, 2017



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