EVISA is not only informing about all aspects of chemical speciation but actively promoting research in this field.
Research supported by EVISA is meant to:
- provide easy and robust methods for speciation analysis
- enhance the quality of analytical results and the information provided by speciation analysis
- enhance the knowledge about the biological activity, function and toxicity of chemical species
The following studies were done with EVISA participation (newest first):
2019
Jennifer-Christin Müller, Maximilian Horstmann, Lisa Traeger, Andrea U. Steinbicker,
Michael Sperling,
Uwe Karst,
µXRF and LA-ICP-TQMS for quantitative bioimaging of iron in organ samples of a hemochromatosis model, J. Trace Elem. Med. Biol., 52 (2019) 166-175.
DOI: 10.1016/j.jtemb.2018.12.012
David Clases, Stefanie Fingerhut, Astrid Jeibmann,
Michael Sperling, Philip Doble,
Uwe Karst,
LA-ICP-MS/MS
improves limits of detection in elemental bioimaging of gadolinium
deposition originating from MRI contrast agents in skin and brain
tissues, J. Trace Elem. Med. Biol., 51 (2019) 212-218.
doi: 10.1016/j.jtemb.2018.10.021
2018
S. Kröger, A.C. Niehoff, A. Jeibmann,
M. Sperling, W. Paulus, W. Stummer,
U. Karst, Complementary Molecular and Elemental Mass Spectrometry Imaging of Human Brain Tumors Resected by Fluorescence-Guided Surgery, Anal. Chem., 90/20 (2018) 12253-60.
doi: 10.1021/acs.analchem.8b03516
Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe,
Michael Sperling, Rita Schröter, Marta Kantauskaitč, Yohannes Hagos,
Uwe Karst, Stephen J. Lippard and Giuliano Ciarimboli,
Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations, Front. Chem., 6 (2018) #180.
DOI: 10.3389/fchem.2018.00180
Stefanie Fingerhut,
Michael Sperling, Markus Holling, Thomas Niederstadt, Thomas Allkemper, Alexander Radbruch, Walter Heindel, Werner Paulus, Astrid Jeibmann,
Uwe Karst,
Gadolinium‑based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study, Acta Neuropathol., 136 (2018) 127-138.
DOI: 10.1007/s00401-018-1857
Oliver Bolle Bauer, Christina Köppen,
Michael Sperling, Hans-Joachim Schurek, Giuliano Ciarimboli, and
Uwe Karst,
Quantitative Bioimaging of Platinum via Online Isotope Dilution-Laser Ablation-Inductively Coupled Plasma Mass Spectrometry, Anal. Chem., 90 (2018) 7033−7039.
DOI: 10.1021/acs.analchem.8b01429
Jennifer-Christin Müller, Josef Lichtmannegger, Hans Zischka,
Michael Sperling,
Uwe Karst,
High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment, Journal of Trace Elements in Medicine and Biology 49 (2018) 119127.
DOI: 10.1016/j.jtemb.2018.05.009 David Clases,
Michael Sperling,
Uwe Karst,
Analysis of Metal-based Contrast Agents in Medicine and the Environment, Trends Anal. Chem., 104 (2018) 135-147.
DOI: 10.1016/j.trac.2017.12.011 Stefanie Fingerhut, Ann-Christin Niehoff,
Michael Sperling, Astrid Jeibmann, Werner Paulus, Thomas Niederstadt, Thomas Allkemper, Walter Heindel, Markus Holling,
Uwe Karst,
Spatially
resolved quantification of gadolinium deposited in the brain of a
patient treated with gadolinium-based contrast agents, J. Trace Elem. Med. Biol., 45 (2018) 125-130.
DOI: 10.1016/j.jtemb.2017.10.004
2017
G.M. Thyssen, M. Holtkamp, H. Kaulfürst-Soboll,
C.A. Wehe,
M. Sperling, A. von Schaewen,
U. Karst,
Elemental bioimaging by means of LA-ICP-OES: investigation of the calcium, sodium and potassium distribution in tobacco plant stems and leaf petioles, Metallomics, 9/6 (2017) 676-684.
doi: 10.1039/C7MT00003K Oliver Hachmöller, Michaela Aichler, Kristina Schwamborn, Lisa Lutz, Martin Werner ,
Michael Sperling, Axel Walch and
Uwe Karst,
Investigating the influnce of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry, J. Trace Elem. Med. Biol., 44 (2017) 7175.
DOI: 10.1016/j.jtemb.2017.06.002 Oliver Hachmöller, Andree Zibert, Hans Zischka,
Michael Sperling, Sara Reinartz Groba, Inga Grünewald, Eva Wardelmann, Hartmut H.-J. Schmidt,
Uwe Karst,
Spatial investigation of the elemental distribution in Wilsons disease liver after D-penicillamine treatment by LA-ICP-MS, J. Trace Elem. Med. Biol., 44 (2017) 26-31.
DOI: 10.1016/j.jtemb.2017.05.008
2016
Marvin Birka, Jörg Roscher, Michael Holtkamp,
Michael Sperling,
Uwe Karst,
Investigating the stability of gadolinium based contrast agents towards UV radiation, Water Res., 91 (2016) 244-250.
DOI: 10.1016/j.watres.2016.01.012 Oliver Hachmöller, Ana Guilherme Buzanich, Michaela Aichler, Martin Radtke, Dörthe Dietrich, Kristina Schwamborn, Lisa Lutz, Martin Werner,
Michael Sperling, Axel Walch and
Uwe Karst,
Elemental bioimaging and speciation analysis for the investigation of Wilsons disease using µXRF and XANES, Metallomics, 8 (2016) 648-653.
DOI: 10.1039/c6mt00001k Marvin Birka,
Christoph A. Wehe, Oliver Hachmöller,
Michael Sperling,
Uwe Karst,
Tracing gadolinium-based contrast agents from surface water to drinking water by means of speciation analysis, J. Chromatogr. A, 1440 (2016) 105-111.
DOI: 10.1016/j.chroma.2016.02.050 Oliver Hachmöller, Michaela Aichler, Kristina Schwamborn, Lisa Lutz, Martin Werner,
Michael Sperling, Axel Walch,
Uwe Karst,
Element bioimaging of liver needle biopsy specimens from patients with Wilsons disease by laser ablation-inductively coupled plasma-mass spectrometry, J. Trace Elem. Med. Biol., 35 (2016) 97102.
DOI: 10.1016/j.jtemb.2016.02.001
2015
Chun Kong Mak,
Christoph A. Wehe,
Michael Sperling,
Uwe Karst,
Identification and quantification of electrochemically generatedmetabolites of thyroxine by means of liquidchromatography/electrospray-mass spectrometry andcountergradient liquid chromatography/inductively coupled plasma-mass spectrometry, J. Chromatogr. A, 1419 (2015) 8188.
DOI: 10.1016/j.chroma.2015.09.076 C. Köppen, O. Reifschneider, I. Castanheira,
M. Sperling,
U. Karst and G. Ciarimboli,
Quantitative imaging of platinum based on laser ablation-inductively coupled plasma-mass spectrometry to investigate toxic side effects of cisplatin, Metallomics, 7 (2015) 1595-1603.
DOI: 10.1039/c5mt00226e Rebecca Niehaus,
Michael Sperling and
Uwe Karst,
Study on aerosol characteristics and fractionation effects of organic standard materials for bioimaging by means of LA-ICP-MS, J. Anal. At. Spectrom., 30 (2015) 2056-2065.
DOI: 10.1039/c5ja00221d Christoph A. Wehe, Georgina M. Thyssen, Christina Herdering, Indra Raj, Giuliano Ciarimboli,
Michael Sperling,
Uwe Karst,
Elemental Bioimaging by Means of Fast Scanning Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry, J. Am. Soc. Mass Spectrom. 26/8 (2015) 1274-1282.
DOI: 10.1007/s13361-015-1141-y Olga Reifschneider, Kristina S. Wentker, Klaus Strobel, Rebecca Schmidt, Max Masthoff,
Michael Sperling, Cornelius Faber,
Uwe Karst,
Elemental Bioimaging of Thulium in Mouse Tissues by Laser Ablation-ICPMS as a Complementary Method to Heteronuclear Proton Magnetic Resonance Imaging for Cell Tracking Experiments, Anal. Chem. , 87 (2015) 4225-4230.
DOI: 10.1021/ac504363q
Olga Reifschneider, Christian L. Schütz, Christoph Brochhausen, Gabriele Hampel, Tobias Ross,
Michael Sperling,
Uwe Karst,
Quantitative bioimaging of p-boronophenylalanine in thin liver tissue sections as a tool for treatment planning in boron neutron capture therapy, Anal. Bioanal. Chem. 407 (2015) 23652371.
DOI 10.1007/s00216-014-8012-4
2014
Christoph A. Wehe, Imke Pieper, Michael Holtkamp, Georgina M. Thyssen,
Michael Sperling, Tanja Schwerdtle,
Uwe Karst, On-line species-unspecific isotope dilution analysis in the picomolar range reveals the time- and species-depending mercury uptake in human astrocytes, Anal Bioanal Chem, 406 (2014) 9091916.
DOI 10.1007/s00216-013-7608-4 Christoph A. Wehe, Georg Beyer,
Michael Sperling, Giuliano Ciarimboli,
Uwe Karst,
Assessing the intracellular concentration of platinum in medulloblastoma cell lines after Cisplatin incubation, J. Trace Elem. Med. Biol., 28 (2014) 166172.
doi: 10.1016/j.jtemb.2014.01.001 Stefan Trümpler, Björn Meermann, Sascha Nowak, Wolfgang Buscher,
Uwe Karst,
Michael Sperling,
In vitro study of thimerosal reactions in human whole blood and plasma surrogate samples, J. Trace Elem. Med. Biol., 28 (2014) 125130.
doi: 10.1016/j.jtemb.2014.01.006 Christoph A. Wehe, Ann-Christin Niehoff, Georgina M. Thyssen,
Michael Sperling,
Uwe Karst,
Rapid cell mode switching and dual laser ablation inductively coupled plasma mass spectrometry for elemental bioimaging, Rapid Commun. Mass Spectrom., 28 (2014) 26272635.
DOI: 10.1002/rcm.7054 Franziska Blaske, Olga Reifschneider, Georg Gosheger,
Christoph A. Wehe,
Michael Sperling,
Uwe Karst, Gregor Hauschild, Steffen Höll,
Elemental Bioimaging of Nanosilver-Coated Prostheses Using X-ray Fluorescence Spectroscopy and Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry, Anal. Chem., 86 (2014) 615-620.
doi: 10.1021/ac4028577 Sascha Nowak, Monika Gesell, Michael Holtkamp, Andy Scheffer,
Michael Sperling,
Uwe Karst,
Wolfgang Buscher,
Low gas flow inductively coupled plasma optical emission spectrometry for the analysis of food samples after microwave digestion, Talanta, 129 (2014) 575578.
doi: 10.1016/j.talanta.2014.06.045 Ann-Christin Bülter, Aline Moosmann, Judith Söbbing, Arno Wiehe, Dennis Mulac,
Christoph Alexander Wehe, Olga Reifschneider, Franziska Blaske, Sylvia Wagner,
Michael Sperling, Hagen von Briesen, Klaus Langer,
Uwe Karst, A Palladium Label to Monitor Nanoparticle-Assisted Drug Delivery of a Photosensitizer into Tumor Spheroids by Elemental Bioimaging, Metallomics, 6/1 (2014) 77-81.
DOI: 10.1039/C3MT00223C
2013
Christina Herdering, Olga Reifschneider,
Christoph A. Wehe,
Michael Sperling,
Uwe Karst,
Ambient molecular imaging by laser ablation atmospheric pressure chemical ionization mass spectrometry, Rapid Commun. Mass Spectrom., 27 (2013) 25952600.
DOI: 10.1002/rcm.6727 Christina Herdering,
Christoph A. Wehe, Olga Reifschneider, Indra Raj, Giuliano Ciarimboli, Kurt Diebold, Christoph Becker,
Michael Sperling,
Uwe Karst,
Laser ablation based bioimaging with simultaneous elemental and
molecular mass spectrometry: towards spatially resolved speciation
analysis, Rapid Commun. Mass Spectrom., 27 (2013) 25882594.
DOI: 10.1002/rcm.6726 Franziska Blaske, Lisa Stork,
Michael Sperling,
Uwe Karst,
Adduct formation of ionic and nanoparticular silver with amino acids and glutathione, J. Nanopart. Res., 15 (2013) 1928.
DOI 10.1007/s11051-013-1928-3 Olga Reifschneider,
Christoph A. Wehe, Indra Raj, Jens Ehmcke, Giuliano Ciarimboli,
Michael Sperling,
Uwe Karst,
Quantitative bioimaging of platinum in polymer embedded mouse organs using laser ablation ICP-MS, Metallomics, 5 (2013) 1440-1447.
DOI: 10.1039/c3mt00147d
Marvin Birka,
Christoph A. Wehe, Lena Telgmann,
Michael Sperling,
Uwe Karst,
Sensitive quantification of gadolinium-based magnetic resonance imaging contrast agents in surface waters using hydrophilic interaction liquid chromatography and inductively coupled plasma sector field mass spectrometry, J. Chromatogr. A, 1308 (2013) 125-131.
DOI: 10.1016/j.chroma.2013.08.017 Michael Holtkamp, Tim Elseberg,
Christoph A. Wehe,
Michael Sperling,
Uwe Karst,
Complexation and oxidation strategies for improved TXRF determination of mercury in vaccines, J. Anal. At. Spectrom., 28 (2013) 719-723.
DOI: 10.1039/c3ja00002h
Olga Reifschneider,
Christoph A. Wehe, Kurt Diebold, Christoph Becker,
Michael Sperling,
Uwe Karst, Elemental bioimaging of haematoxylin and eosin-stained tissues by laser ablation ICP-MS, J. Anal. At. Spectrom., 28 (2013) 989-993.
DOI: 10.1039/c3ja50046b
Christine Brauckmann,
Christoph A. Wehe, Michael Kieshauer, Claudia Lanvers-Kaminsky,
Michael Sperling,
Uwe Karst,
The interaction of platinum-based drugs with native biologically relevant proteins, Anal. Bioanal. Chem., 405 (2013) 1855-1864.
DOI: 10.1007/s00216-012-6410-z Christine Brauckmann, Helene Faber, Claudia Lanvers-Kaminsky,
Michael Sperling, Uwe Karst,
Influence of cimetidine and its metabolites on CisplatinInvestigation of adduct formation by means of electrochemistry/liquid chromatography/electrospray mass spectrometry, J. Chromatogr. A., 1279 (2013) 4957.
DOI: 10.1016/j.chroma.2012.12.069 Lena Telgmann,
Michael Sperling,
Uwe Karst,
Speciation of Gd-based MRI contrast agents in biological and environmental samples: A review, Anal. Chim. Acta, 764 (2013) 1-16.
DOI: 10.1016/j.aca.2012.12.007
2012
L. Telgmann,
C.A. Wehe, M. Birka, J. Künnemeyer, S. Nowak,
M. Sperling,
U. Karst,
Speciation and Isotope Dilution Analysis of Gadolinium-Based Contrast Agents in Wastewater, Environ. Sci. Technol., 46 (2012) 11929-11936.
DOI: 10.1021/ES301981Z L. Telgmann,
C.A. Wehe, J. Künnemeyer, A.-C. Bülter,
M. Sperling,
U. Karst,
Speciation of Gd-based MRI contrast agents and potential products of transmetalation with iron ions or parenteral iron supplements, Anal. Bioanal. Chem., 404 (2012) 2133-2141.
DOI: 10.1007/S00216-012-6404-X M. Holtkamp,
C.A. Wehe, F. Blaske, C. Holtschulte,
M. Sperling,
U. Karst,
Nitrogen purged TXRF for the quantification of silver and palladium, J. Anal. Atomic Spectrom., 27 (2012) 1799-1802.
DOI: 10.1039/C2JA30117B Bjoern Meermann,
Michael Sperling, Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications, Anal. Bioanal. Chem., 403 (2012) 15011522.
DOI: 10.1007/S00216-012-5915-9 Lena Telgmann, H. Faber, S. Jahn, D. Melles, H. Simon,
M. Sperling,
U. Karst, Identification and Quantification of Potential Metabolites of Gd-Based Contrast Agents by Electrochemistry/Separations/Mass Spectrometry, J. Chromatogr. A, 1240 (2012) 147155.
2011
Michael Sperling, Joanna Szpunar,
Speciation Issue: Editorial, J. Anal. At. Spectrom., 26 (2011) 22.
DOI: 10.1039/c0ja90031a
C.A. Wehe, J. Bornhorst, M. Holtkamp,
M. Sperling, H.-J. Galla,
Tanja Schwerdtle,
U. Karst,
Fast and low sample consuming quantification of manganese in cell nutrient solutions by flow injection ICP-QMS, Metallomics, 3/12 (2011) 12911296.
DOI: 10.1039/C1MT00170A L. Telgmann, M. Holtkamp, J. Künnemeyer, C. Gelhard, M. Hartmann, A. Klose,
M. Sperling,
U. Karst,
Simple and rapid quantification of gadolinium in urine and blood plasma samples by means of total reflection X-ray fluorescence (TXRF), Metallomics, 30 (2011) 1766-1773.
DOI: 10.1039/c1mt00054c R. Janzen, M. Schwarzer,
M. Sperling, M. Vogel,
T. Schwerdtle,
U. Karst, Adduct formation of Thimerosal with human and rat hemoglobin: a study using liquid chromatography coupled to electrospray time-of-flight mass spectrometry (LC/ESI-TOF-MS), Metallomics, 3/8 (2011) 847852.
DOI: 10.1039/C1MT00043H
2010
S. Bomke,
M. Sperling,
U. Karst,
Organometallic derivatizing agents in bioanalysis, Anal. Bioanal. Chem., 397 (2010) 3483-3494.
DOI: 10.1007/s00216-010-3611-1 A. Wilken, R. Janzen, M. Holtkamp, S. Nowak,
M. Sperling, M. Vogel,
U. Karst, Investigation of the interaction of Mercurochrome constituents with proteins using liquid chromatography/mass spectrometry, Anal. Bioanal. Chem., 397 (2010) 3525-3532.
DOI: 10.1007/S00216-010-3842-1
2009
S. Trümpler, S. Nowak,
B. Meermann, G. A. Wiesmüller,
W. Buscher,
M. Sperling,
U. Karst,
Detoxification of mercury speciesan in vitro study with antidotes in human whole blood , Anal. Bioanal. Chem., 395 (2009) 1929-1935.
DOI: 10.1007/s00216-009-3105-1
before 2008
Kevin Francesconi,
Michael Sperling,
Speciation analysis with HPLC-mass spectrometry: time to take stock, The Analyst, 130 (2005) 998-1001.
DOI: 10.1039/b504485p M. Sperling,
W. Buscher, O.F.X. Donard, R. Cornelis,
L. Ebdon,
Transfer of Know-how and Knowledge in the Area of Speciation Analysis from research Institutions to Industry - The European Virtual Institute for Speciation Analysis (EVISA), RMZ-Materials and Geoenvironment, 51 (2004) 2030-2032.
R. Cornelis,
W. Buscher,
M. Sperling, O.F.X. Donard, N. Proust,
E. Rosenberg,
R. Milacic,
The EC networking on elemental speciation revisited, Accred. Qual. Assur., 9 (2004) 268-271 (2004).
DOI: 10.1007/s00769-004-0761-xlast time modified: January 2, 2019
