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Special issue on "Advances in speciation techniques and methodology" available


Special issue:

Cover of the "Speciation" special issue of "trends in Analytical Chemistry"The special issue published in "Trends in Analytical Chemistry" is a collection of invited reviews by renowed scientists being active in the field of speciation analysis. In their editorial, the editors give a brief review about the importance of speciation analysis and its development over the last 50 years. During the development of speciation analysis, the use of techniques has been shifted from primarily atomic spectrometry to detect elemental species separated by different chromatographic and non-chromatographic separation techniques towards mass spectrometry.

Maria Montes-Bayon et al. from the University of Oviedo presents an overview of the use of elemental and molecular mass spectrometry as the tools for speciation analysis. The group of authors clearly show the trend to apply molecular mass spectrometry supported by software search engines to monitor elemental tags and to extract the structural and quantitative information by combined use with elemental mass spectrometry. Philip Doble et al. is reviewing chromatographic separation techniques coupled with ICP-MS discussing their intrinsic features that must be considered when designing speciation experiments. These authors also expect that future developments in mass spectrometry (ICP-QQQ-MS, ICP-TOF-MS) will further improve the versatility of ICP-MS for speciation analysis.

Franceso Porcaro et al. give an overview of synchrotron-based techniques for elemental speciation in biomedical research. Special attention is paid to metal-based drug biotransformation, metal and nanoparticle toxicology, and elemental speciation in cancer, neurological, and general pathophysiology. Justyna Wojcieszek et al. discuss the challenging speciation analysis of technology-critical elements (TCEs): Ga, Ge, In, Nb, Ta, Te, Tl, and most of the platinum group elements (PGEs) and rare earth elements (REEs) that occur at the low trace levels.  Fabienne Seby and Veronique Vacchina present a synopsis of methods for the analysis of chromium species in different solid samples (soils/wastes, working atmosphere, industrial and food samples) paying particular attention to possible interconversion and methods to avoid or correct for this.

Sara Gutierrez Sama et al. review the speciation analysis of crude oils and heavy petroleum fractions, discussing the important role of high-resolution mass spectrometry to overcome the lacking selectivity of chromatographic separation which is necessary to investigate the metal speciation in crude oil beyond the simple porphyrins. Ghaya AlChoubassi et al. review the state-of-the art of methods for iron speciation in plant samples. They show that dual separation-mechanism (SEC and HILIC) HPLC with dual ICP MS and ESI MS detection provide a comprehensive speciation of low molecular weight iron complexes in micro- or nanoliter volumes of plant fluids. Katarzyna Bierla et al. are critically discussing the recent advances in selenium speciation analysis, especially in terms of sensitivity and specificity of ICP-MS and electrospray-MS. Zuzana Gajdosechova et al.  summarize the state of the art of current analytical techniques focusing on the interactions between mercury and selenium in biological matrices.

Holtkamp and Hartinger are discussing some novel analytical Metallomics methods utilizing mass spectrometric detectors often hyphenated with separation systems, and their application to anticancer metallodrug research. Their emphasis is on the value of speciation analysis for the development of new anticancer agents with improved efficacy. Balazs Klencsar et al. review the current status of (U)HPLC-ICPMS(/MS) for the analysis of drugs not containing a metal. Besides the possibilities to monitor the most important (non-metal) hetero-elements in pharmaceuticals, the reviewers also discuss derivatization strategies for drugs lacking an element detectable by ICP-MS.

David Clases et al. discuss current issues and developments regarding the role and the analysis of metal species used as contrast agents in radiology and nuclear medicine. Laura Cid-Barrio et al. review the reliable and direct protein and peptide quantification with ICP-MS that nicely complements the structural information provided by molecular mass spectrometry in proteomics. Michalke et al. evaluate recent speciation findings in neurodegeneration research concentrating on measurements in cerebrospinal fluid and brain tissue. The enhanced information obtained by speciation analysis allows to discriminate less important species from compounds significant for the disease. Qing-qing Liu et al.  summarize recent advances in speciation analysis of phenylarsenicals. HPLC coupled to ICP-MS and ESI-MS has enabled the identification and quantification of metabolites and improved our understanding of the fate of phenylarsenicals and the potential risk of human exposure. Finally, Julia Bornhorst et al. review the situation of adequate biomarkers for the trace element species of Se, Mn, Zn and Cu and conclude that there is only a limited understanding of putative interactions between the trace elements.

The editors express their hope that these 16 reviews by prominent groups from the field of speciation analysis provide an overview of recent developments and give an outlook for future directions.

Reviews in the special issue

Michael Sperling, Uwe Karst, Editorial: Advances in speciation techniques and methodology, Trends Anal. Chem., 104 (2018) 1-3. DOI: 10.1016/j.trac.2018.04.006

M. Montes-Bayon, M. Sharar, M. Corte-Rodriguez, Trends on (elemental and molecular) mass spectrometry based strategies for speciation and metallomics, Trends Anal. Chem. 104 (2018) 4-10. DOI: 10.1016/j.trac.2017.09.025

D.P. Bishop, D.J. Hare, D. Clases, P.A. Doble, Applications of liquid chromatography-inductively coupled plasma-mass spectrometry in the biosciences: a tutorial review and recent developments, Trends Anal. Chem., 104 (2018) 11-21. DOI: 10.1016/j.trac.2017.09.017

F. Porcaro, S. Roudeau, A. Carmona, R. Ortega, Advances in element speciation analysis of biomedical samples using synchrotron-based Techniques, Trends Anal. Chem., 104 (2018) 22-41. DOI: 10.1016/j.trac.2017.09.016

J. Wojcieszek, J. Szpunar, R. Lobinski, Speciation of technologically critical elements in the environment using chromatography with element and molecule specific detection, Trends Anal. Chem., 104 (2018) 42-53. DOI: 10.1016/j.trac.2017.09.018

F. Seby, V. Vacchina, Critical assessment of hexavalent chromium species from different solid environmental, industrial and food matrices, Trends Anal. Chem., 104 (2018) 54-68. DOI: 10.1016/j.trac.2017.11.019

S. Gutierrez Sama, C. Barrere-Mangote, B. Bouyssiere, P. Giusti, R. Lobinski, Recent trends in element speciation analysis of crude oils and heavy petroleum fractions, Trends Anal. Chem. 104 (2018) 69-76. DOI: 10.1016/j.trac.2017.10.014

G. AlChoubassi, J. Aszyk, P. Pisarek, K. Bierla, L. Ouerdane, J. Szpunar, R. Lobinski, Advances in mass spectrometry for iron speciation in plants, Trends Anal. Chem., 104 (2018) 77-86. DOI: 10.1016/j.trac.2017.11.006

K. Bierla, S. Godin, R. Lobinski, J. Szpunar, Advances in electrospray mass spectrometry for the selenium speciation: focus on Se-rich yeast, Trends Anal. Chem., 104 (2018) 87-94. DOI: 10.1016/j.trac.2017.10.008

Z. Gajdosechova, Z. Mester, J. Feldmann, E.M. Krupp, The role of selenium in mercury toxicity e current analytical techniques and future trends in analysis of selenium and mercury interactions in biological matrices, Trends Anal. Chem., 104 (2018) 95-109. DOI: 10.1016/j.trac.2017.12.005

H.U. Holtkamp, C.G. Hartinger, Advanced metallomics methods in anticancer metallodrug mode of action studies, Trends Anal. Chem., 104 (2018) 110-117. DOI: 10.1016/j.trac.2017.09.023

B. Klencsar, S. Li, L. Balcaen, F. Vanhaecke, High-performance liquid chromatography coupled to inductively coupled plasma - mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of non-metal drugs, Trends Anal. Chem., 104 (2018) 118-134. DOI: 10.1016/j.trac.2017.09.020

D. Clases, M. Sperling, U. Karst, Analysis of metal-based contrast agents in medicine and the environment, Trends Anal. Chem., 104 (2018) 135-147. DOI: 10.1016/j.trac.2017.12.011

L. Cid-Barrio, F. Calderon-Celis, P. Abasolo-Linares, M.L. Fernandez-Sanchez, J.M. Costa-Fernandez, J. Ruiz Encinar, A. Sanz-Medel, Advances in absolute protein quantification and quantitative protein mapping using ICP-MS, Trends Anal. Chem. 104 (2018) 148-159. DOI: 10.1016/j.trac.2017.09.024

B. Michalke, D. Willkommen, E. Drobyshev, N. Solovyev, The importance of speciation analysis in neurodegeneration research, Trends Anal. Chem., 104 (2018) 160-170. DOI: 10.1016/j.trac.2017.08.008

Q.Q. Liu, X.F. Lu, H.Y. Peng, A. Popowich, J. Tao, J.S. Uppal, X.W. Yan, D. Boe, X.C. Le, Speciation of arsenic - A review of phenylarsenicals and related arsenic metabolites, Trends Anal. Chem. 104 (2018) 171-182. DOI: 10.1016/j.trac.2017.10.006

J. Bornhorst, A.P. Kipp, H. Haase, S. Meyer, T. Schwerdtle, The crux of inept biomarkers for risks and benefits of trace elements, Trends Anal. Chem., 104 (2018) 183-190. DOI:  10.1016/j.trac.2017.11.007

Related EVISA Resources

Books and Special issues related to speciation analysis

Chapters on techniques and methodology for speciation analysis:

Chapter 1: Tools for elemental speciation
Chapter 2: ICP-MS - A versatile detection system for speciation analysis
Chapter 3: LC-ICP-MS - The most often used hyphenated system for speciation analysis
Chapter 4: GC-ICP-MS- A very sensitive hyphenated system for speciation analysis
Chapter 5: CE-ICP-MS for speciation analysis
Chapter 6: ESI-MS: The tool for the identification of species
Chapter 7: Speciation Analysis - Striving for Quality
Chapter 8: Atomic Fluorescence Spectrometry as a Detection System for Speciation Analysis
Chapter 9: Gas chromatography for the separation of elemental species
Chapter 10: Plasma source detection techniques for gas chromatography
Chapter 11: Fractionation as a first step towards speciation analysis
Chapter 12: Flow-injection inductively coupled plasma mass spectrometry for speciation analysis
Chapter 13: Gel electrophoresis combined with laser ablation inductively coupled plasma mass spectrometry for speciation analysis
Chapter 14: Non-chromatographic separation techniques for speciation analysis

Brief summaries

About Speciation

   Speciation as a discipline in Analytical Chemistry – Definitions   
   Why should elemental speciation be done ?
   Why is elemental speciation analysis not done routinely ?
   Speciation analysis as a tool to enhance the quality of life
   Speciation and Toxicity

Research fields related to elemental speciation

   Chemical speciation analysis for the life sciences
   Chemical speciation analysis for nutrition and food science
   Trace element speciation analysis for environmental sciences
   Speciation analysis for the study of metallodrugs and their biomolecular interactions

Speciation Analysis - Striving for Quality

   Problems to be solved in the field of speciation analysis
   Error sources in speciation analysis - Overview
   Sample preservation for speciation analysis - General recommendations
   Species transformation during speciation analysis
   Certified Reference Materials for Chemical Speciation Analysis
   Standard methods for elemental speciation analysis

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