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Increased global mortality linked to dietary exposure to inorganic arsenic via rice-based diets



Rice is the most widely consumed staple food source for a large part of the world’s population. It has now been confirmed that rice can contribute to prolonged low-level arsenic exposure leading to thousands of avoidable premature deaths per year.

Especially inorganic arsenic is well known acute poison, but it can also contribute to health problems, including cancers and cardiovascular diseases, if consumed at even relatively low concentrations over an extended period of time.

Compared to other staple foods, rice tends to concentrate inorganic arsenic. Across the globe, over three billion people consume rice as their major staple and the inorganic arsenic in that rice has been estimated by some to give rise to over 50,000 avoidable premature deaths per year.

A collaborating group of cross-Manchester researchers from The University of Manchester and The University of Salford have published new research exploring the relationship, in England and Wales, between the consumption of rice and cardiovascular diseases caused by arsenic exposure.

Their findings, published in the journal Science of the Total Environment, shows that - once corrected for the major factors known to contribute to cardiovascular disease (for example obesity, smoking, age, lack of income, lack of education) there is a significant association between elevated cardiovascular mortality, recorded at a local authority level, and the consumption of inorganic arsenic bearing rice.

Professor David Polya from The University of Manchester said: “The type of study undertaken, an ecological study, has many limitations, but is a relatively inexpensive way of determining if there is plausible link between increased consumption of inorganic arsenic bearing rice and increased risk of cardiovascular disease.

“The study suggests that the highest 25% of rice consumers in England and Wales may plausibly be at greater risks of cardiovascular mortality due to inorganic arsenic exposure compared to the lowest 25% of rice consumers.

“The modelled increased risk is around 6% (with a confidence interval for this figure of 2% to 11%). The increased risk modelled might also reflect in part a combination of the susceptibility, behaviours and treatment of those communities in England and Wales with relatively high rice diets.”

While more robust types of study are required to confirm the result, given many of the beneficial effects otherwise of eating rice due to its high fibre content, the research team suggest that rather than avoid eating rice, people could consume rice varieties, such as basmati, and different types like polished rice (rather whole grain rice) which are known to typically have lower inorganic arsenic contents. Other positive behaviours would be to eat a balanced variety of staples, not just predominately rice.

The lead author, Ms Lingqian Xu, is a President's Doctoral Scholarship Award recipient from The University of Manchester and supervised by Professor David Polya (The University of Manchester) and Dr Debapriya Mondal (University of Salford). Mr Qian Li is a former Masters of Pollution and Environmental Control (MPEC) student from The University of Manchester.

This article has been republished from the following materials. Note: material may have been edited for length and content.

The original study:

Lingqian Xu, David A Polya, Qian Li, Debapriya Mondal. Association of low-level inorganic arsenic exposure from rice with age-standardized mortality risk of cardiovascular disease (CVD) in England and Wales. Sci. Total. Environ., 743 (2020) 140534. doi: 10.1016/j.scitotenv.2020.140534

Related studies (newest first)

L.-Q. Xu, D. Mondal, D.A. Polya, Positive Association of Cardiovascular Disease (CVD) with chronic exposure to drinking water arsenic (As) at concentrations below the WHO provisional guideline value: a systematic review and meta-analysis. Int. J. Environ. Res. Public Health 17 (2020) 2536. DOI: 10.3390/ijerph17072536.

K.A. Moon, A. Navas-Acien, M. Grau-Pérez, K.A. Francesconi, W. Goessler, E. Guallar,  Low-moderate urine arsenic and biomarkers of thrombosis and inflammation in the Strong Heart Study. PLoS ONE 12/8 (2017) e0182435. DOI: 10.1371/journal.pone.0182435

K.A. Moon, S. Oberoi, A. Barchowsky, Y. Chen, E. Guallar, K.E. Nachman, A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease. Int. J. Epidemiol. 46 (2017) 1924–1939. DOI: 10.1093/ije/dyx202.

S.F. Farzan, Y. Chen, J.R. Rees, M.S. Zens, M.R. Karagas, Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicol. Appl. Pharmacol. 287 (2015) 93–97. DOI: 10.1016/j.taap.2015.05.013

K.A. Moon, E. Guallar, J.G. Umans, R.B. Devereux, L.G. Best, K.A. Francesconi, Association between exposure to low to moderate arsenic levels and incident cardiovascular disease. Ann. Intern. Med. 159 (2013) 649–659. DOI: 10.7326/0003-4819-159-10-201311190-00719.

M.J. Medrano, R. Boix, R. Pastor-Barriuso, M. Palau, J. Damián, R. Ramis, J.L. del Barrio, A. Navas-Acien, Arsenic in public water supplies and cardiovascular mortality in Spain. Environ. Res., 110 (2010) 448–454. DOI: 10.1016/j.envres.2009.10.002

F. Wu, F. Jasmine, M.G. Kibriya, M. Liu, O. Wójcik, F. Parvez, R. Rahaman, S. Roy, R. Paul-Brutus, S. Segers, V. Slavkovich, T. Islam, D. Levy, J.L. Mey, A. van Geen, J.H. Graziano, H. Ahsan, Y. Chen, Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers. Am. J. Epidemiol. 175 (2012) 1252–1261. DOI: 10.1093/aje/kwr464.

Related EVISA News (newest first):

November 14, 2013: Arsenic Speciation in Rice Cereals for Infants
May 15, 2013: Arsenic species in rice: Origin, uptake and geographical variation
February 15, 2013: JRC-IRMM has released ERM-BC211 certified rice reference material for arsenic speciation analysis
September 21, 2012: Arsenic in Rice : First results from the U.S. Food and Drug Administration
January 4, 2011: Arsenic species in rice: Call for analytical laboratories
May 19, 2010: China: Inorganic Arsenic in Rice - An Underestimated Health Threat ?
December 4, 2009: EFSA: Scientific Opinion on Arsenic in Food
May 26, 2009: UK Food Standards Agency releases research on arsenic in rice milk
July 18, 2008: Experts detail how rice absorbs arsenic from the soil 
March 15, 2008: Arsenic in rice milk exceeds EU and US drinking water standards
February 15, 2008:
Arsenic speciation in rice: a question of the rice plant species
March 7, 2007: Elevated Arsenic Levels Found In Rice Grown In South Central States of the USA
September 7, 2006: New Agilent HPLC column for routine determination of arsenic species in human urine by HPLC-ICP-MS

last time modified: August 9, 2020


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