The establishment of EVISA is funded by the EU through
the Fifth Framework Programme (G7RT- CT- 2002- 05112).
Supporters of EVISA includes:
Iodothyronine deiodinase ( 188.8.131.52 ) (DI) is the
vertebrate enzyme responsible for the deiodination of the prohormone
thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically
active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive
metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of
about 250 residues that contain a selenocysteine at their active site.
Three types of DI selenoenzymes are known, type II is essential for
providing the brain with the appropriate levels of T3 during the
critical period of development, and type III is essential for the
regulation of thyroid hormone inactivation during embryological