The establishment of EVISA is funded by the EU through
the Fifth Framework Programme (G7RT- CT- 2002- 05112).
Supporters of EVISA includes:
orally bioavailable copper salt of D-gluconic acid. In addition to its
roles as an enzyme cofactor for cytochrome C oxidase and superoxide
dismutase, copper forms complexes with the thiocarbamate disulfiram
(DSF) forming DSF-copper complexes, which enhances the DSF-mediated
inhibition of the 26S proteasome; proteasome inhibition may result in
inhibition of cellular protein degradation, cessation of cell cycle
progression, inhibition of cellular proliferation, and the induction of
apoptosis in susceptible tumor cell populations.