US EPA Method 8323: Determination of organotins by microliquid chromatography-electrospray ion trap mass spectrometry
Method 8323 [PDF File, 22 pages, 119 KB, January 2003]
Determination of Organotins by Micro-Liquid Chromatography- Electrospray Ion Trap Mass Spectrometry
Method 8323 is the first product of an OSW project to develop a series of class-specific Electrospray HPLC/MS methods to replace the obsolete Thermospray interface currently used in Method 8321. When the project is complete, OSW will issue a single integrated Electrospray HPLC/MS method. Method 8323 covers the use of solid-phase extraction (SPE) discs, solvent extractions (for biological tissues) as sample preparation methods, and micro-liquid chromatography ( LC) coupled with Electrospray ion trap mass spectrometry (ES-ITMS) [this technique would also be applicable to ES-quadrupole mass spectrometry (ES-MS)] for the determination of organotins (as the cation) in waters and biological tissues.
Keywords: tributyltin chloride, dibutyltin choride, monobutyltin chloride, triphenyltin chloride, diphenyltin dichloride, monophenyltin trichloride.