For various synthesis applications
Monowave 300 was developed and investigated in cooperation with one of the world’s leading academic microwave laboratories. Based on this experience, the instrument has been optimized with respect to easy handling and low maintenance in addition to impressive performance and utmost monitoring precision.
Monowave 300 reaches a new level in microwave assisted organic synthesis since it combines utmost user safety and facilitation of daily lab-work with the highest Anton Paar standards in terms of product quality, precise measurement and reaction control. Due to the prevention of temperature overshoots cleaner products (less by-products) can be obtained. With its operation limits of 300 °C and 30 bar, Monowave 300 opens up new reaction pathways for operation in R&D scale.
Efficient heating and unique vessel material
The extremely high field density guarantees outstanding heating rates in any scale and for any solvent. In addition to the standard borosilicate glass vials, a SiC vessel is available which provides ultra-fast heating even for microwave transparent reaction mixtures. Since SiC is chemically inert, fluorinations can also be performed without detaching the vessel material.
Monowave 300 accomodates 4 different reaction vials and volumes between 0.5 mL and 20 mL. The vials are sealed leak-proof with a PEEK snap cap and a PTFE-coated silicone septum - all consumables are completely reusable items. Due to the same neck sizes of the reaction vials, one and the same cap and septum can close any reaction vial just with the click of a thumb. In case of remaining post reaction overpressure the vials are automatically depressurized during the opening process of the cavity cover.
Sophisticated temperature measurement
In addition to the IR sensor, the optional Ruby Thermometer can be used for accurate temperature monitoring. It is a fiber optic probe sensor for internal temperature control based on the temperature-dependent luminescence of a ruby crystal. With this simultaneous internal and IR temperature feedback reactions can be precisely controlled and monitored.
Seamless automation with MAS 24
Monowave 300 can be easily upgraded with the autosampler MAS 24, which is placed on top of the reactor to save valuable lab space. MAS 24 provides unattended, sequential operation of up to 24 reactions in individual scales for focused library generation as well as for small-range scale-up. Sample mix-ups are avoided due to the software-guided loading strategy which ensures convenient and intuitive handling.
Direct method transfer to Masterwave BTR
Small range scale up can be easily accomplished with Monowave 300 by employing different reaction vessels and sequential automation with MAS 24. If larger scales are required, the optimized protocol can be directly transferred to Masterwave BTR. Both reactors provide the same user interface, which allows direct method transfer and convenient and intuitive experiment programming.